The discovery of the most powerful antibody to the “Corona virus”

The discovery of the most powerful antibody to the “Corona virus”
The discovery of the most powerful antibody to the “Corona virus”

In a glimmer of hope towards eliminating the emerging corona virus, researchers were able to discover a monoclonal antibody that targets the spike protein in the corona virus, and is effective in neutralizing all its mutations, including the delta strain.

According to Medical Express, the findings by researchers at the University Hospital of Lausanne (CHUV) and the Federal Institute of Technology in Lausanne (EPFL) have been published in the prestigious journal Cell Reports.

The researchers isolated a newly identified antibody using lymphocytes from emerging coronavirus patients enrolled in the ImmunoCoV study being conducted at Lausanne University Hospital.

This is the most powerful antibody identified so far against the emerging corona virus, and the characterization of the antibody indicated that it binds to a region that is not subject to spike protein mutations.

Stopping the reproduction of the virus

Through this tight interaction, a monoclonal antibody can prevent the Spike protein from binding to cells that express the ACE2 receptor, which is the receptor that the virus uses to enter and infect lung cells, which means that the antibody stops the multiplication process of the virus, which enables the patient’s immune system to eliminate the virus. Novel Corona.

Amazing results

This protection mechanism was proven through in vivo tests on animals, as the samples that were given to the antibody were protected from infection even after receiving a severe dose of the emerging corona virus infection, in addition to its antiviral properties, the new antibody was designed to have Lasting effect on humans.

good protection

A typical, unchanged antibody protects the body for up to 3-4 weeks, but this new drug can protect patients for 4-6 months, making it an interesting preventive treatment option for at-risk unimmunized or vaccinated individuals unable to produce an immune response.

Immunodeficiency patients

As for protecting immunocompromised patients, transplant recipients, and those with certain types of cancer from the emerging coronavirus by receiving antibody injections two or three times a year, the researchers now plan to build on these promising results in partnership with a startup that will conduct clinical development and production. An antibody-containing drug, through cooperation agreements and intellectual property, and clinical trials of this treatment are expected to begin in late 2022.

The discovery of this new antibody is a major step forward in the fight against corona. It opens the door to improved treatments for severe forms of the disease and for enhanced preventive measures, especially for patients with weakened immune systems. At the same time, this antibody is not intended to replace the corona vaccines that It remains the most effective way to prevent corona infection.

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