An association between hypercholesterolemia and the aggressiveness of bladder cancer

Washington – Arab Today

Hypercholesterolemia is defined as a common metabolic disorder, a term used to refer to a high level of cholesterol in the blood. Studies have reported hypercholesterolemia as a risk factor in the development of cancers derived from steroid-targeted tissues, such as breast cancer and prostate cancer. However, less is known about the effects of hypercholesterolemia on target nonsteroidal cancers, such as bladder cancer.

In a study published in the journal Cancer Research, a team of researchers led by Yan Jun of Fudan University, Huang Ruimin of the Shanghai Institute of Medical Materials under the Chinese Academy of Sciences, and Gu Hongqian of Nanjing University School of Medicine, uncovered a new mechanism on how low-density lipoprotein (LDL) protein acts. Oxidative stress-induced hypercholesterolemia (ox-LDL) enhances bladder cancer aggressiveness.

Using two different hypercholesterolemic mouse models, the researchers demonstrated that high cholesterol can promote the development of bladder cancer by regulating cancer stemness.

Consistent with this idea, inhibition of intestinal cholesterol absorption with ezetimibe reversed diet-induced hypercholesterolemia and the cancer stem, suggesting that high cholesterol was the primary cause of bladder cancer aggressiveness.

This study first established the link between hypercholesterolemia and bladder cancer. and showed that elevated oxidized low-density lipoprotein (LDL)-induced hypercholesterolemia (ox-LDL) may act as a risk factor for bladder cancer. The ox-LDL-induced hypercholesterolemia was a major factor in promoting cancer-like cells, providing an example of the tumor macroenvironment in regulating cancer stems.

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