Good news for owners of “chronic disease” .. “new medicine” when needed

Good news for owners of “chronic disease” .. “new medicine” when needed
Good news for owners of “chronic disease” .. “new medicine” when needed

Rheumatoid arthritis is a chronic inflammatory disease that can affect areas other than the joints. It can damage a wide range of body systems, including the skin, eyes, lungs, and heart and blood vessels, causing damage to cartilage and bone.

Although there are effective treatments for “rheumatoid arthritis”, it causes side effects as a result of its continuous use and in high doses..

In a study recently published in the journal Science Advances, scientists say the research team’s ultimate goal is to develop treatments for people with rheumatoid arthritis, a debilitating condition that affects about 1.3 million adults in the United States..

They note that their research on cell culture, in mouse models of rheumatoid arthritis, demonstrated the effectiveness of the proposed treatment, as it significantly reduced inflammation and prevented bone erosion..

cartilage implant

With some clarification, senior researcher Farshid Guilak says: “Doctors often treat patients with rheumatoid arthritis by injecting biological anti-inflammatory drugs, but these treatments can cause significant side effects when given long enough and in high doses, so that they have beneficial effects on disease.

As for the drug’s strategy, Mildred Simon, a professor of orthopedics and co-author of the study, says: “We used CRISPR technology to reprogram genes in stem cells, and then we created a small cartilage implant by implanting the cells on woven scaffolds, and placing it under the skin of mice.“.

She explains: “This method allows these cells to remain in the body for a long time, and they release the drug whenever there is inflammation“.

Researchers use genome editing technology CRISPR-Cas9 To make cells that secrete a biological drug, the drug reduces joint inflammation by binding to interleukin-1 (IL-1)It is a substance that often promotes inflammation in osteoarthritis.

Guillac and his team developed scaffolds, covered them with stem cells, and then transplanted them into joints to form cartilage. The strategy allows the researchers to implant the engineered chondrocytes in a way that does not drift away after a few days and can remain viable for several months..

The researchers also built so-called smart chondrocytes (modified stem cells for self-regenerative therapy) using a technology CRISPR-Cas9 To alter the genes in those cells, so that when genes in cartilage are activated by inflammation, they release drugs in response.

The new technology opens wide prospects for scientists to develop effective treatments, as it is possible through gene editing technology CRISPR-Cas9The cells have the ability to be programmed to produce all kinds of drugs, which means that if one arthritis drug works better than another in a particular patient, researchers can engineer the cartilage cells to make customized treatments.

 
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